- Over het proefschrift: This thesis covers our scientific findings on the immunopathogenic role, the transcriptional regulation and the diagnostic use of the Epstein-Barr virus BARF1 gene. Includes an explicit introductory chapter on Epstein-Barr virus and its association with disease, and a state-of-the-art review about BARF1 Over de auteur: Eveline Karina Hoebe was born on May 12th, 1980, in Alkmaar, the Netherlands. From an early age she was interested in biology and gene technology, instigated by sheep Dolly and bull Herman. She graduated from high school (HAVO) in 1998 at the Bonhoeffer College in Castricum and at that same year she started her Laboratory (Bio)Chemistry training (HLO) at the University of Applied Sciences in Alkmaar. Eveline was an active member of the students board (PR and sponsoring) of A.S.V. Omnivas. For her graduation project she studied genetic markers for disease resistance genes in brassica (cabbage) at Bejo zaden Warmenhuizen. After obtaining her Bachelor degree in 2002, she started as a research technician at the VU University Medical Center at the Department of Oncology where she worked on adenovius genetherapy for glioma. In 2004 she moved to the Pharmacology group where she studied the effects of various drug combinations. In 2007 she started as a PhD student in the Epstein-Barr virus group of the Department of Pathology under supervision of Prof. Dr. J.M. Middeldorp and Dr. A.E. Greijer. Part of her research was performed at the McArdle laboratory for cancer research at the University of Wisconsin under supervision of Prof. S.C. Kenney. The results of her research are presented in this thesis entitled: Epstein-Barr virus encoded BARF1 protein: immunopathogenic role, transcriptional regulation and diagnostic use in nasopharyngeal carcinoma.